Sierra Leone

PLOS MEDICINE   by Ben Cooper and others                                                             April 14, 2015
Experimental treatments for Ebola virus disease might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic

A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stages, including both non-randomised and randomised elements. The probabilities of rightly or wrongly recommending the experimental treatment, the required sample size, and the consequences for epidemic outcomes over 100 d under two epidemic scenarios were compared for the MSA, a sequential randomised controlled trial (SRCT) with up to 20 interim analyses, and, as a reference case, a conventional randomised controlled trial (RCT) without interim analyses.

Read complete study.

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001815

THE GUARDIAN by Sam Jones                                                              April 7, 2015

Africa’s efforts to tackle the Ebola crisis have been largely overlooked even though Africans have taken the lead in providing frontline staff and shown themselves “better placed to fight infectious diseases in their continent than outsiders”, according to the African Union (AU).

A Liberian health worker checks the temperature of students to curb the spread of Ebola in Caldwell, outside the capital Monrovia. Photograph: Ahmed Jallanzo/EPA

Dr Olawale Maiyegun, director of social affairs at the AU commission, said that despite the fact that Africans had proved both willing and able to deal with Ebola, the focus had been on the work of international agencies and those with the greatest media clout.

ASSOCIATED PRESS  by Sarah DiLorenzo                                                               April 2, 2015      

(Scroll below for related Wall Street Journal story.)   

DAKAR, Senegal (AP) — When will the world's largest and longest Ebola outbreak end? The West African countries of Sierra Leone and Liberia both appear to be on steady paths to ending the epidemic. The wild card is Guinea, where Ebola hasn't burned as hot but remains stubbornly entrenched.

In this file photo dated Friday, March. 27, 2015, a usually busy street is deserted as Sierra Leone enters a three day country wide lockdown on movement of people due to the Ebola virus in the city of Freetown, Sierra Leone. Sierra Leone's 6 million people were told to stay home for three days, except for religious services, beginning Friday as the West African nation attempted a final push to rid itself of Ebola. (AP Photo/ Michael Duff, FILE)

Liberia's last Ebola patient died March 27; it is now counting down the 42 days it must wait to be declared free of Ebola. Meanwhile, Sierra Leone recorded no new infections Wednesday for the second time; on average, it has logged a handful each day in recent days.

The Vaccine Confidence Project    2015
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE