Study indicates mix-and-match Covid vaccine approach boosts immune response

Mixing different types of Covid vaccines can boost immune response, study finds Some European countries have started offering alternatives to AstraZeneca as a second shot after the vaccine was linked to rare blood clots. NBC News

A mixed schedule of vaccines where a shot of Pfizer's Covid-19 vaccine is given four weeks after an AstraZeneca shot will produce better immune responses than giving another dose of AstraZeneca, an Oxford study said on Monday.

The study, called Com-COV, compared mixed two-dose schedules of Pfizer and AstraZeneca vaccines, and found that in any combination, they produced high concentrations of antibodies against the coronavirus spike protein.

The data provides support for the decision of some European countries that have started offering alternatives to AstraZeneca as a second shot after the vaccine was linked to rare blood clots.

Matthew Snape, the Oxford professor behind the trial, said that the findings could be used to give flexibility to vaccine rollouts, but was not large enough to recommend a broader shift away from clinically approved schedules on its own.

"It's certainly encouraging that these antibody and T-cell responses look good with the mixed schedules," he told reporters.

"But I think your default has to stay, unless there's a very good reason otherwise, to what is proven to work," he added referring to the same-shot vaccine schedules assessed in clinical trials.

The highest antibody response was seen in people receiving two doses of Pfizer vaccine, with both mixed schedules producing better responses than two doses of AstraZeneca vaccine. ...