PLOS MEDICINE   by Ben Cooper and others                                                             April 14, 2015
Experimental treatments for Ebola virus disease might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic

A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stages, including both non-randomised and randomised elements. The probabilities of rightly or wrongly recommending the experimental treatment, the required sample size, and the consequences for epidemic outcomes over 100 d under two epidemic scenarios were compared for the MSA, a sequential randomised controlled trial (SRCT) with up to 20 interim analyses, and, as a reference case, a conventional randomised controlled trial (RCT) without interim analyses.

Read complete study.

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001815

INTERNATIONAL BUSINESS TIMES  by Morgan Winsor        April 17, 2015

A strange disease has ravaged a small community in western Nigeria, killing at least 14 people in the last 10 days. Residents of the Ikale community in Ondo state have described the mysterious epidemic as more deadly than Ebola and many are afraid to touch the dead, the Daily Post in Nigeria reported.

“We are worried. Our people are dying. We don’t know this sickness,” resident Mary Omogbehinla told the Daily Post on Thursday. “We can’t touch those who have been killed. I have counted about 19, others said 14. God please, have mercy on us.”

Four new patients with symptoms of the strange disease were isolated at a local hospital in Ode Irele. The state’s health commissioner, Dayo Adeyanju, said Thursday the government launched an awareness campaign to encourage residents to report any potential cases of the mysterious ailment. The World Health Organization (WHO), Nigeria’s health ministry and other health agencies were also contacted to help identify the disease and to ensure the cases do not spread, the Daily Post said Thursday.

TAKEPART.COM by Jessica Dollin                                                                     April 14, 2015

Ebola dominated headlines this past year, but the epicenter of the outbreak wasn’t on a map until after the virus had infected and killed thousands. Without geographical resources, aid workers were tasked with the challenge of navigating remote areas to locate people in need of assistance.

PLOS CURRENT OUTBREAKS  by Saheed Gidado and others                                                    April 8, 2015
The first ever outbreak of Ebola virus disease (EVD) in Nigeria was declared in July, 2014. Level of public knowledge, perception and adequacy of information on EVD were unknown. We assessed the public preparedness level to adopt disease preventive behavior which is premised on appropriate knowledge, perception and adequate information.

Methods: We enrolled 5,322 respondents in a community-based cross-sectional study. We used interviewer-administered questionnaire to collect data on socio-demographic characteristics, EVD–related knowledge, perception and source of information...

THE GUARDIAN by Sam Jones                                                              April 7, 2015

Africa’s efforts to tackle the Ebola crisis have been largely overlooked even though Africans have taken the lead in providing frontline staff and shown themselves “better placed to fight infectious diseases in their continent than outsiders”, according to the African Union (AU).

A Liberian health worker checks the temperature of students to curb the spread of Ebola in Caldwell, outside the capital Monrovia. Photograph: Ahmed Jallanzo/EPA

Dr Olawale Maiyegun, director of social affairs at the AU commission, said that despite the fact that Africans had proved both willing and able to deal with Ebola, the focus had been on the work of international agencies and those with the greatest media clout.

NEW YORK TIMES OP-ED  By BERNICE DAHN, VERA MUSSAH and CAMERON NUTT   April 7, 2015               
MONROVIA, Liberia — The conventional wisdom among public health authorities is that the Ebola virus, which killed at least 10,000 people in Liberia, Sierra Leone and Guinea, was a new phenomenon, not seen in West Africa before 2013. (The one exception was an anomalous case in Ivory Coast in 1994, when a Swiss primatologist was infected after performing an autopsy on a chimpanzee.)

ASSOCIATED PRESS  by Sarah DiLorenzo                                                               April 2, 2015      

(Scroll below for related Wall Street Journal story.)   

DAKAR, Senegal (AP) — When will the world's largest and longest Ebola outbreak end? The West African countries of Sierra Leone and Liberia both appear to be on steady paths to ending the epidemic. The wild card is Guinea, where Ebola hasn't burned as hot but remains stubbornly entrenched.

In this file photo dated Friday, March. 27, 2015, a usually busy street is deserted as Sierra Leone enters a three day country wide lockdown on movement of people due to the Ebola virus in the city of Freetown, Sierra Leone. Sierra Leone's 6 million people were told to stay home for three days, except for religious services, beginning Friday as the West African nation attempted a final push to rid itself of Ebola. (AP Photo/ Michael Duff, FILE)

Liberia's last Ebola patient died March 27; it is now counting down the 42 days it must wait to be declared free of Ebola. Meanwhile, Sierra Leone recorded no new infections Wednesday for the second time; on average, it has logged a handful each day in recent days.

VOICE OF AMERICA by Benno Muchler                          March 30, 015
MONROVIA—For Liberian survivors of Ebola, the struggle is not over.  Many have lost property and family members, and often face tremendous stigma after being released from the hospital. Unresolved medical issues are another problem.  Despite their suffering, they are still waiting for support a year into the Ebola crisis.

People shun them.  Landlords terminate their leases.  Some lost their jobs.  Many survivors also suffer from headaches and eye problems.  Doctors do not know yet if these Ebola side effects are only temporary.

To make their voices heard, survivors formed a network under the umbrella of Liberia’s Ministry of Health and Social Welfare last September.

Korlia Bonarwolo was part of that, but then broke away and formed his own group. He said that after months without support, it seemed to him the government only used survivors to attract foreign aid.

When misinformation is a case of life or death, aid workers and communities need an ear to the ground

INTERNEWS   by  Anahi Ayala Iacucci                                                March 26, 2015

 What is now clear to healthcare organizations working on the ground in West Africa is that the Ebola epidemic has been driven as much by misinformation and rumors as by weaknesses in the health system. It is common sense that information is a critical element in combatting disease, particularly when contagion from common social practices, such as bathing the corpses of the deceased, were central to so much of the early spread of the disease. But in the context of a massive disease outbreak, when hundreds of international organizations and billions of dollars flood into a region whose fragile infrastructure has been damaged by years of civil war, information dissemination becomes a powerful challenge.

The Vaccine Confidence Project    2015
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE 

EUROSURVEILLANCE by I. Goodfellow, C. Reusken, and M. Koopmans  

  March 26, 2015                                                              

The Ebola virus epidemic in West Africa is on the brink of entering a second phase in which the (inter)national efforts to slow down virus transmission will be engaged to end the epidemic. The response community must consider the longevity of their current laboratory support, as it is essential that diagnostic capacity in the affected countries be supported beyond the end of the epidemic.

The emergency laboratory response should be used to support building structural diagnostic and outbreak surveillance capacity.

SCIENCE NEWS  by Ashley Yaeger                                                      March 26, 2015

(Scroll down for full study.)

The virus causing the current Ebola epidemic in West Africa is not evolving as quickly as some scientists had suggested.

REGULAR RATE  A genetic analysis suggests that the Ebola virus, shown here in orange, is not evolving as fast as expected.

In a paper last August, researchers reported that the virus (Zaire ebolavirus) was altering its genes almost twice as fast as it had during previous Ebola outbreaks in Central Africa (SN: 9/20/14, p. 7). However, a new genetic analysis shows that the virus is mutating at roughly the same rate as in past outbreaks, researchers report online March 26 in Science. The finding suggests the virus has not become more virulent or transmissible during the West Africa outbreak.

PLOS MEDICINE by Mark J. Siedner, Lawrence O. Gostin, Hilarie H. Cranmer,and John D. Kraemer                        March 24, 2015

In-depth paper on lessons learned from the West Africa Ebola outbreak

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

sciencedirect.com - June 2014
Justin Stoler, Rawan al Dashti, Francis Anto, Julius N. Fobil, Gordon A. Awandare
doi:10.1016/j.actatropica.2014.02.017

CLICK HERE - Deconstructing “Malaria”: West Africa as the Next Front for Dengue Fever Surveillance and Control

Highlights

• Febrile illnesses are vastly overdiagnosed as malaria in many African settings.

• West Africa is emerging as a new front for dengue fever surveillance and control.

• Efficient health care utilization depends upon proper diagnosis of febrile illness.