DESIGN & TREND  by Randall Mayes                                                                             Nov. 29, 2014

Over the last decade, we have witnessed the emergence of Superbugs, various strains of bird flu and now Ebola, which do not have geographical borders.

Consequently, there is a pressing need for international cooperation to control these pandemics.

In a new study, researchers have identified obstacles that are currently preventing the world from sharing health data, reports Science Daily.

While performing a literature search for the study, an international group of researchers discovered over 1,400 scientific articles related to sharing public health data. From those articles, they found two broad categories that need to be addressed.

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http://www.designntrend.com/articles/28008/20141129/urgent-need-improved-infrastructure-share-health-data.htm

Link to article  in Science Daily
http://www.sciencedaily.com/releases/2014/11/141125102102.htm

REUTERS                                                                                                                      NOV. 28, 2014

LONDON --Men who recover from Ebola should abstain from sex for three months to minimize the risk of passing the virus on in their semen, the World Health Organization (WHO) said on Friday.

Ebola, a disease that has infected and killing thousands in a vast epidemic in West Africa, normally spreads via bodily fluids such as blood, saliva and faeces. Although sexual transmission of Ebola virus disease has never been documented, the virus has been detected in the survivors' semen.

"Men who have recovered from Ebola virus disease should be aware that seminal fluid may be infectious for as long as three months after onset of symptoms," the WHO said in a statement....

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http://www.reuters.com/article/2014/11/28/us-health-ebola-sex-idUSKCN0JC0UP20141128

Description of efforts by the big drug companies to develop an Ebloa vaccine
THE NEW YORKER    By Vauhine Vara                        Nov. 25, 2014

"...why this race to create an Ebola vaccine among Merck, GlaxoSmithKline, and Johnson & Johnson—three of the world’s biggest drug manufacturers? For years, pharmaceutical companies didn’t invest much in vaccines, partly because they were so costly and complicated to produce: they’re often made out of live bacteria, which are notoriously difficult to work with. But, over the past several years, companies have realized that the difficulties of making vaccines could be an asset, because they can make it more difficult for generic-drug companies to create copycat versions than for prescription drugs. The vaccine market has also been growing more quickly than the prescription-drug market. The World Health Organization estimates, based on various sources, that global vaccine sales rose from five billion dollars in 2000 to twenty-four billion dollars last year...."

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http://www.newyorker.com/business/currency/race-ebola-vaccine

PLOS CURRENT OUTBREAKS                                                                              Nov. 21, 2014
By David Fisman and Ashleigh Tuite, Dalla Lana School of Public Health, University of Toronto

As removal of population-level susceptibility through vaccination could be a highly impactful control measure for this epidemic, we sought to estimate the number of vaccine doses and timing of vaccine administration required to reduce the epidemic size. Our base model was fit using the IDEA approach, a single equation model that has been successful to date in describing Ebola growth. We projected the future course of the Ebola epidemic using this model. Vaccination was assumed to reduce the effective reproductive number. We evaluated the potential impact of vaccination on epidemic trajectory under different assumptions around timing of vaccine availability.

Benno Muchler - November 25, 2014 - qz.com

Ebola was one of the biggest news stories this year. What did we learn from it? Not much. Panic and fear replaced rational thinking. And there was another pernicious behavior we didn’t change.

Ebola would have been a chance to start differentiating Africa. Yet, we’re doing quite the opposite. We continue to look at Africa as one country. We act as if the whole continent is contaminated. And most sadly, outside Africa we stigmatize Africans, no matter which part of the continent they’re from, because of Ebola.

Read the whole article here:

http://qz.com/301707/people-are-treating-africa-like-a-country-because-of-ebola/

INTERNAL DISPLACEMENT MONITORING CENTRE                                                                            Nov.19, 2014

When a whole town was displaced in the south of Guinea during the Ebola crisis, the link between disease and displacement began to emerge. With IDMC monitoring the crisis across the three countries most affected since the outbreak took place, we have identified five key displacement trends emerging.

On 14 November 2014 the UN Mission for Ebola Emergency Response (UNMEER) reported that the Guinean government had announced the withdrawal of troops from Womey, Nzérékoré prefecture, in the south of the country when a group of people raising awareness about the Ebola Virus Disease (EVD) were killed by angry residents.

Since the army’s deployment in September, there have been accusations of human rights violations at the hands of military personnel, resulting in the displacement of the whole town, with some 6,000 residents fleeing to forests in the surrounding area. This is the single largest reported incident of displacement during the Ebola crisis.

NBC NEWS    By Maggie Fox                                                                              Nov. 24, 2014

Two outbreaks, two entirely different outcomes. The World Health Organization has declared an outbreak of Ebola over in the Democratic Republic of Congo after just 66 cases and 49 deaths. It lasted three months.

Yet the epidemic in Liberia, Sierra Leone and Guinea’s been going for nine months, with more than 15,000 cases, 5,000 deaths and no end in sight.

What’s the difference? Experts say experience matters — it was the seventh outbreak in the former Zaire. But equally important is the fact that the village where it started was extremely remote, and the country has a rudimentary system of healthcare workers who know to look out for Ebola.

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http://www.nbcnews.com/storyline/ebola-virus-outbreak/tale-two-outbreaks-why-congo-conquered-ebola-n253911

                                                                                                    Getty Images

WIRED                 BY Katie M. Palmer                                                    Nov. 24, 214

The FDA announced Friday that it would start developing a stockpile of blood plasma from Ebola survivors, treated with a pathogen inactivation system that’s never been used before in the United States.

So far, the US has had some amazing success in curing Ebola, possibly thanks to experimental plasma treatments. Drawn from survivors, the stuff comes enriched in antibodies that could help to fight off the disease—but it also has the potential to carry other diseases, like malaria, that are common in west Africa where Ebola is raging. The new system will kill off any extra contaminants that may be lurking in this potentially live-saving serum.

It’s the same one, Cerus Corporation’s Intercept system, that will be used in a Gates Foundation-funded study of Ebola treatments in West Africa. The pathogen-killing molecule at the heart of the system is amotosalen, part of a class of three-ringed molecules called psoralens....

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NBC NEWS       By Nikita Japra                                                                                     Nov. 23, 2014
In a darkened Boston conference room, staring at projections from a laptop, John Brownstein is far from the front lines of the fight against Ebola. But the epidemiologist’s work may help change the course of the epidemic.

The disease forecaster and his team are combing through news reports, tweets and Facebook posts to anticipate the disease’s next move — and help those on the ground head it off before the crisis grows....

Brownstein’s HealthMap scours social media and local news from around the globe to locate potential hot spots and display them in an interactive map. In the past, HealthMap has spotted outbreaks ranging from H1N1 swine flu to Dengue fever. Today, the team is building interactive maps that can guide the response to the worst Ebola outbreak ever recorded.

While official numbers from government agencies can take precious time to confirm, Brownstein’s team looks to more immediate, unconventional sources to help target the right communities at the right time.

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USA TODAY                       By Greg Zoraya                                                                                 Nov. 23, 2014

MONROVIA, Liberia — A snapshot of the Ebola epidemic raging across West Africa shows a wildfire of infections only slightly contained.

While cases have been on the decline in Liberia, the outbreak is worsening in neighboring countries, where basic Ebola-fighting tools are impractical.

Identifying the infected and those they've touched, and isolating them to break the transmission chain are all but impossible in Sierra Leone's capital of Freetown as well as the jungles of Guinea, says Jordan Tappero, the Centers for Disease Control and Prevention's second-in-command for the regional response...

New research suggests that Ebola's deadly inflammatory effects may be caused by the result of protein shedding by infected cells. (Victor Volchkov / PLOS Pathogens)

CLICK HERE - RESEARCH - PLOS Pathogens - Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

latimes.com - by Monte Morin - November 20, 2014

New research suggests that the massive and destructive inflammation that characterizes Ebola virus disease may be caused by the release of foreign proteins from infected cells.

Although Ebola is infamous for causing bleeding in some of its victims, doctors say the vast majority of deaths are the result of organ failure and shock brought on by the uncontrolled release of cytokines, compounds that cells use to communicate with one another and control immune response. . .

. . . In a paper published Thursday in Plos Pathogens, researchers at the Claude Bernard University of Lyon, in France, argued that glycoprotein shedding by infected cells may explain the immune system's damaging response.

THE GUARDIAN                                                    Nov. 21, 2014
THE UNITED NATIONS --The UN security council has criticized travel bans against nationals from Ebola-hit countries.

Last month the Australian immigration minster, Scott Morrison, announced Australia would stop granting temporary visas to visitors from west Africa. The security council statement criticised such blanket bans and urged countries to maintain links with affected countries.

“The security council expresses its continued concern about the detrimental effect of the isolation of the affected countries as a result of trade and travel restrictions imposed on and to the affected countries as well as acts of discrimination against the nationals of Guinea, Liberia, Mali and Sierra Leone,” said Julia Bishop, the Australian foreign mniister who was presiding over the session Thursday.

The council statement also described the Ebola outbreeak in Africa as "a threat to international peace and security..."

WALL STREET JOURNAL                                                                                               Nov. 21, 2014

By Andrew Morse

ZURICH—Nearly 5,500 people have died from Ebola, the World Health Organization said Friday, adding that the rate of transmission remains intense in the three West African countries at the center of the epidemic.

Medical staff members of the Croix Rouge NGO put on protective suits before collecting the corpse of a victim of Ebola, in Monrovia, Liberia. Agence France-Presse/Getty Images

In an update, the United Nations health agency said 15,351 confirmed, suspected or probable cases of Ebola had been reported in eight countries that have been affected by the disease. Most of the cases were concentrated in Guinea, Liberia and Sierra Leone.

A total of 5,459 people have died of Ebola since the outbreak began, the WHO said. On Wednesday, the WHO reported 15,145 cases and 5,420 deaths.

Ebola’s true overall toll is difficult to gauge because some hard-hit villages are remote and urban centers have showed resistance toward clinics....

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VOICE OF AMERICA                                                                                                       Nov. 21, 2014

The World Health Organization has declared an end to the Ebola outbreak in the Democratic Republic of Congo.

The outbreak -- unrelated to the one affecting West Africa -- was centered in Congo's northwestern Equateur province and killed at least 49 people.  Nurses from Uganda’s Ministry of Health check passengers arriving from Democratic Republic of Congo, Central Africa at Entebbe Airport Kampala Uganda, Friday, Aug. 8, 2014.

The WHO released a statement Friday saying it has been 42 days, or twice the maximum incubation period, since a new case of Ebola has been detected in the DRC.

The WHO declaration confirms a statement by the DRC government last week that the outbreak there is over.

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http://www.voanews.com/content/who-declares-end-to-ebola-outbreak-in-drc/2529068.html

See complete WHO statement

VOICE OF AMERICA                                                                                                        Nov. 20, 2014
By Joe DeCapua
Knowing where the Ebola hot spots are in a country is crucial to getting an outbreak quickly under control. Many have criticized the initial slow response to the West Africa outbreak, saying it’s a big reason the virus quickly spread. Now, a German research center is developing a project to monitor Ebola and other outbreaks in real time.

Professor Gérard Krause said the new project – called EBOKON – uses real-time monitoring to better manage an outbreak.Krause is head of the Department of Epidemiology at the Helmholtz Center for Infection Research – and EBOKON project leader for the German Center for Infection Research....

He said, “This is an information technology tool that we are developing together with colleagues from Nigeria that will take care of all those management aspects.”

The EBOKON project calls for setting up a command center, so to speak, in the capital of affected countries. Then health workers would use cellphones to relay in real time information on suspected cases around the country.