Health-care workers struggle to help people who have been traumatized by the epidemic.

The Ebola epidemic in West Africa may be fading, but its impact on mental health could linger for years. Survivors are often haunted by traumatic memories and face rejection by society when they return home, and those who never contracted the disease may grieve for lost relatives or struggle to cope with extreme anxiety.

The trauma caused by death and fear is having long-term ramifications on the people of Sierra Leone.

LIVE SCIENCE  by Rahael Retner                             March 5, 2015

Texas nurse Nina Pham, who was infected with Ebola, says she has had ongoing health problems since being cured of the disease, and experts say this is not uncommon for Ebola survivors.

The long-term effects of Ebola have not been well studied, and doctors will likely learn a lot more about the disease's aftermath from the most recent outbreak in West Africa, the largest in history, said Dr. Jesse Goodman, an infectious-disease expert and a professor of medicine at Georgetown University Medical Center in Washington, D.C.

 But it is clear that Ebola survivors can experience health problems that remain with them temporarily as a result of their battle with the disease, Goodman said....

 These symptoms may result, in part, from the body's release of certain immune-system chemicals called cytokines. These chemicals fight the disease but make people feel sick. Dehydration, low blood pressure and nutrition problems that people experience during an Ebola infection can also injure a person's muscles or other tissues, Goodman said.

 REUTERS By Daniel Flynn, James Harding Giahyue and Saliou Samb                              Feb. 27, 2015

The Radisson Blu chain opened the four-star hotel in April to cater for investors in one of Africa's fastest-growing economies. A month later, Ebola crossed the border from Guinea and those investors fled....

For months, Sierra Leone was cut off from the world amid panic at the worst recorded outbreak of the hemorrhagic fever, which has killed more than 9,500 people in Sierra Leone, Guinea and Liberia and infected over 23,500.

But with infection rates slowly declining, investors have begun to talk about post-Ebola reconstruction. Neves has noted the return of businessmen not seen since the hotel opened.

"They don't bring their teams. They just come to see what is going on and then they leave," he said, adding that 'business as usual' remains far off. "This will be a year focused on Ebola. First the fight to end Ebola and then reconstruction...."

REUTERS                                                           Feb. 26, 2015

Diagnostics company Corgenix Medical Corp said on Thursday U.S. health regulators had approved its rapid Ebola test for emergency use, in response to the world's worst outbreak of the virus that killed more than 10,000 so far.

The company's ReEBOV Antigen Rapid Test, which involves putting a drop of blood on a paper strip and waiting for at least 15 minutes for a reaction, was cleared by the World Health Organization last week.

The test is less accurate than the standard test, which has a turnaround time of 12-24 hours, but is easy to perform and does not require electricity. It is able to correctly identify about 92 percent of Ebola-infected patients and 85 percent of those not infected with the virus, the WHO said.

The WHO is still assessing four or five other rapid test candidates.

Read complete story.
http://www.reuters.com/article/2015/02/26/us-health-ebola-testing-idUSKBN0LU1OO20150226

REUTERS by Stephanie Nebehay                                                             Feb. 27, 2015

GENEVA -- An independent advisory body will decide in August at the earliest on whether to recommend widespread introduction of an Ebola vaccine, depending on results of clinical trials and the epidemic's course, the World Health Organization said on Friday.

All three worst-hit countries in West Africa - Guinea, Liberia and Sierra Leone - aim to conduct phase III final-stage clinical trials of experimental vaccines.

Liberia is already testing both the GlaxoSmithKline and Merck-NewLink vaccines, while Sierra Leone and Guinea are due to announce plans soon....

WHO spokesman Christian Lindmeier, reporting on a three-day meeting of experts, told a news briefing: "Vaccine introduction is by no means a given and will depend on the results of clinical trials and recommendations from WHO's Strategy Advisory Group of Experts (SAGE) on vaccines and immunization....

Read complete story.

submitted by George Hurlburt

A new paper diagnostic device can detect Ebola as well as other viral hemorrhagic fevers in about 10 minutes. The device (pictured here) has silver nanoparticles of different colors that indicate different diseases. On the left is the unused device, opened to reveal the contents inside. On the right, the device has been used for diagnosis; the colored bands show positive tests.  Photo - Jose Gomez-Marquez, Helena de Puig, and Chun-Wan Yen

Simple paper strip can diagnose Ebola and other fevers within 10 minutes

CLICK HERE - Lab on a Chip - Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Massachusetts Institute of Technology (MIT) - eurekalert.org - February 24, 2015

CAMBRIDGE, MA -- When diagnosing a case of Ebola, time is of the essence. . .

. . . A new test from MIT researchers . . . The device, a simple paper strip similar to a pregnancy test, can rapidly diagnose Ebola, as well as other viral hemorrhagic fevers such as yellow fever and dengue fever. . .

NATIONAL PUBLIC RADIO INTERVIEW by Laura Starecheski                                     Feb. 20, 2015
BARKEDU,  LIBERIA --If you'd like to get an idea of what resilience is all about, take a lesson from Mamuedeh Kanneh.

She lost her husband to Ebola. But she's stayed strong. She's caring for 13 children, her own and orphans whose parents died of the virus.

Mamuedeh Kanneh was married to Laiye Barwor, the man who brought Ebola to Barkedu, Liberia. He died of the virus. She now cares for her children as well as children who lost their parents to the disease. John W. Poole/NPR

Kanneh lives in Barkedu, a village of about 6,000 in northern Liberia. Ebola took more than 150 lives. In her neighborhood there were many deaths, so people in other parts of Barkedu are scared of the orphans.

Kanneh has a strategy to help these children — and the village overall — get back to normal life. She sends the youngsters on errands so people can get used to seeing them and get over their fear. And the children can start to feel they're part of the community again....

NEW YORK TIMES  by Rick Gladstone                                    Feb. 20, 2015

The top two health officials managing the Ebola epidemic cast doubt Friday on a pledge by West African leaders to reduce new cases to zero by mid-April, and expressed concern about a possible rebound of the disease.

 BBC NEWS                                                                                                         Feb. 20, 2015

Liberia is to reopen its borders following a reduction in the number of Ebola cases being reported in the country.

President Ellen Johnson Sirleaf made the announcement on Friday and said nationwide curfews would also be lifted.

New infections have dropped to one-tenth of the level seen when the virus was at its peak.

But health officials warned the decline has levelled off in the last month.

Dr Bruce Aylward, who leads the World Health Organization's official Ebola response, said data showed the steep decrease in infections had now flattened, at a rate of around 120 to 150 new cases a week.

Read complete story.
http://www.bbc.com/news/world-africa-31558363

NEW YORK TIMES  OP-ED BY Ron Klain, the former White House Ebola response coordinaor                                    FEB. 20, 2015

...The world needs to do a better job of quickly detecting and responding to future outbreaks in unlikely places. The President’s Global Health Security Agenda, the government’s strategy to combat infection disease around the world, will help. But vulnerable countries, including those in Africa, need their own version of our Centers for Disease Control and Prevention, so that they are not so dependent on ours.

For the hardest task of front-line epidemic fighting, our planet is too reliant on courageous and talented — but underfunded, under-equipped and volunteer-dependent — nongovernmental organizations. The world needs a permanent standing force — or a ready reserve that can be quickly organized — of public health emergency responders who have the training, gear and resources to race into a region in the early phases of epidemic control. The United States military cannot do that job every time; future outbreaks might occur in countries where our troops will not be welcomed as they were in West Africa.

18 Feb 2015 - Statement by Dr. David Nabarro, Special Envoy of the Secretary-General on Ebola at the informal meeting of the plenary of the General Assembly on the latest developments concerning the Ebola epidemic.

http://webtv.un.org/watch/david-nabarro-on-ebola-informal-meeting-of-the-general-assembly-18-february-2015/4066125793001

CLICK HERE FOR ADDITIONAL RELATED VIDEOS AND SUPPORTING DOCUMENTATION

submitted by Stephen Morse

elifesciences.org - September 8, 2014 - eLife 2014;3:e04395
DOI: http://dx.doi.org/10.7554/eLife.04395

Ebola virus disease (EVD) is a complex zoonosis that is highly virulent in humans. The largest recorded outbreak of EVD is ongoing in West Africa, outside of its previously reported and predicted niche. We assembled location data on all recorded zoonotic transmission to humans and Ebola virus infection in bats and primates (1976–2014). Using species distribution models, these occurrence data were paired with environmental covariates to predict a zoonotic transmission niche covering 22 countries across Central and West Africa. Vegetation, elevation, temperature, evapotranspiration, and suspected reservoir bat distributions define this relationship. At-risk areas are inhabited by 22 million people; however, the rarity of human outbreaks emphasises the very low probability of transmission to humans. Increasing population sizes and international connectivity by air since the first detection of EVD in 1976 suggest that the dynamics of human-to-human secondary transmission in contemporary outbreaks will be very different to those of the past.

 In October, scientists set out to do something unprecedented – conduct a drugs trial during an epidemic to find a treatment for a lethal disease. Could they make history and change the way we deal with outbreaks?

THE GUARDIAN  by Sarah Boseley                           Feb, 17, 2015

In depth description of efforts by a group of Oxford University scientists to run field trials of drugs for use against Ebola.

" ...The little band of scientists had flown to Guinea on 16 October to do something that had never been successfully done before – set up a trial of experimental drugs against an infectious disease in the middle of an epidemic. Because the Ebola virus does not exist at low levels in any population, unless you run a properly conducted trial while the storm is raging, you will never have drugs that are proven to be effective. The Oxford team’s trial would not only aim to find a drug that worked against Ebola but also to establish a blueprint for the way drug trials would be run during outbreaks in the future. This did not just apply to fighting Ebola: if the scientists were successful, their trial would develop protocols for testing drugs for any epidemic, be it Sars or flu...."

Read complete story.

Conakry, Guinea --Statement issued by the heads of Guinea, Liberia and Sierra Leone upon approving an operational framework designed to reduce new Ebola infections to zero within 60 days.

The framework calls for infection prevention and control, social mobilization, community engagement, surveillance, cross border collaboration. 

The leaders also "advocated for a seamless and responsible exit by international partners dictated by the epidemiology and by the adequate transfer of capacity to national institutions."

The statement includes a list of developments and responses.

Read complete statement.

https://ebolaresponse.un.org/sites/default/files/150216-_unmeer_external_situation_report.pdf

Agency seeks a new model after flaws revealed by Ebola crisis.

COMMENTARY MEDPAGE TODAY by Michael Smith            Feb. 15, 2015 

As the Ebola epidemic drags on, the World Health Organization is in danger of losing its credibility as a bulwark against infectious disease.

The West African epidemic is a "mega-crisis (that) overwhelmed the capacity of WHO," according to Director-General Margaret Chan, MD, speaking to reporters in late January.

To prevent a similar crisis in the future, Chan has proposed a package of reforms, including a large contingency fund for emergencies, an increase in the number of trained people able to deploy quickly to a crisis site, and structural changes to streamline the famously unwieldy organization.

Whether those get anywhere is the vital question, according to Lawrence Gostin, JD, of the O'Neill Institute for National and Global Health Law at Washington's Georgetown University.