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Evaluating Clinical Trial Designs for Investigational Treatments of Ebola Virus Disease

PLOS MEDICINE   by Ben Cooper and others                                                             April 14, 2015
Experimental treatments for Ebola virus disease might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic

A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stages, including both non-randomised and randomised elements. The probabilities of rightly or wrongly recommending the experimental treatment, the required sample size, and the consequences for epidemic outcomes over 100 d under two epidemic scenarios were compared for the MSA, a sequential randomised controlled trial (SRCT) with up to 20 interim analyses, and, as a reference case, a conventional randomised controlled trial (RCT) without interim analyses.

Read complete study.

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001815

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Crowdsourced Mapping Could Help Prevent the Next Big Ebola Outbreak

TAKEPART.COM by Jessica Dollin                                                                     April 14, 2015

Ebola dominated headlines this past year, but the epicenter of the outbreak wasn’t on a map until after the virus had infected and killed thousands. Without geographical resources, aid workers were tasked with the challenge of navigating remote areas to locate people in need of assistance.

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The State of Vaccine Confidence

The Vaccine Confidence Project    2015
LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE 

Lead Authors:  Heidi Larson, PhD and Will Schulz, MPH
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Laboratory support during and after the Ebola virus endgame: towards a sustained laboratory infrastructure

EUROSURVEILLANCE by I. Goodfellow, C. Reusken, and M. Koopmans  

  March 26, 2015                                                              

The Ebola virus epidemic in West Africa is on the brink of entering a second phase in which the (inter)national efforts to slow down virus transmission will be engaged to end the epidemic. The response community must consider the longevity of their current laboratory support, as it is essential that diagnostic capacity in the affected countries be supported beyond the end of the epidemic.

The emergency laboratory response should be used to support building structural diagnostic and outbreak surveillance capacity.

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Strengthening the Detection of and Early Response to Public Health Emergencies: Lessons learned from, the Ebola outbreake

PLOS MEDICINE by Mark J. Siedner, Lawrence O. Gostin, Hilarie H. Cranmer,and John D. Kraemer                        March 24, 2015

In-depth paper on lessons learned from the West Africa Ebola outbreak

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Pandemic Disease: Never again

As the Ebola epidemic draws gradually to its close, how should the world arm itself against the risks of insurgent infections?

 THE ECONOMIST                                                                                        March 21,  2015

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Liberians overcome fear to volunteer for Ebola vaccine trial

ASSOCIATED PRESS  by Jpnathan Paye-Layleh             March 22, 2015

MONROVIA, Liberia — Liberians are overcoming their fears of Ebola to volunteer for a vaccine trial...

One year after the World Health Organization declared the Ebola outbreak, vaccine trials are under way in Liberia and Guinea. Sierra Leone will start a trial later this month.

In Liberia, scientists have fanned out across the country to explain the studies and reduce the fear and confusion that have stymied efforts to contain Ebola.

Dr. Stephen Kennedy, the Liberian lead investigator for the study, was among the first people to volunteer for the vaccine trial, getting his injection in front of the media. Similarly, in Guinea, authorities started the study by injecting a series of prominent officials, including the head of the country's Ebola response.

The outreach worked in Liberia, where more than 700 people have volunteered, well beyond the 600 required, according to Kennedy.

Read complete story.
http://news.yahoo.com/liberians-overcome-fear-volunteer-ebola-vaccine-trial-120848405.html

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How to stop the next epidemic

THE ECONOMIST                                                                                    May 19, 2015

..when the next epidemic breaks out, how do we prevent it from spreading around the world? It is easier said than done.
 
First: Early detection is critical, and it relies on good surveillance. But only 64 of the 194 member states of the World Health Organisation (WHO) have the surveillance procedures, laboratories and data-management capabilities required by the International Health Regulations. Improvements in things like basic public health infrastructure are needed...

Second: A swift response to an outbreak – which might involve getting skilled people, equipment and money to the right places – can potentially save more lives than drugs and vaccines. ... The World Health Organisation and the global community were slow to recognise that there was an international public health emergency.

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Congressional Forum - “Building Resilient Communities: Ebola and Global Health Crises – Where We Need to Go”

Dr. David Nabarro - Congressional Forum

upmchealthsecurity.org

CLICK HERE -Agenda

CLICK HERE -Photos

CLICK HERE - Videos

On February 25, 2015 a Congressional Forum was convened.

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3 ways mobile helped stop the spread of Ebola in Nigeria

BROOKINGS TECH TANK   by Joshua Bleiberg and Darrell M. West                                       March 19, 2015

...There were a variety of factors that contributed to Nigeria’s success at combating the (Ebola)  disease. One important factorwas the use of mobile electronic health records programs.

1. Training Healthcare Workers

Training health care providers was a priority at the beginning of the Ebola outbreak. A survey found that 85 percent of health care workers in the country believed you could avoid Ebola by abstaining from handshakes or touching. Correcting these myths about the disease was a critical part of the response effort, especially for health care workers.

2. Rapid Deployment

One of the virtues of mHealth is its speed and flexibility. Mobile allows officials to quickly disseminate the latest information to front line health care workers. Increasing the speed of communication is a general boon to any large public health response.

3. Virtual Records

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