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Lack of Effect of Lamivudine on Ebola Virus Replication

CDC EID JOURNAL by  Lisa E. Hensley, Julie Dyall, Gene G. Olinger, and Peter B. Jahrlin (NIH)                     Feb. 12, 2015

The unprecedented number of Ebola virus disease (EVD) cases in western Africa has compelled the world to consider experimental and off-label therapeutics to mitigate the current outbreak. For clinicians, approved drugs are an attractive solution because of known safety profiles and availability.

Oral lamivudine (GlaxoSmithKline, Brentford, UK), a US Food and Drug Administration–approved anti-HIV drug, has been suggested as a possible antiviral agent against Ebola virus (EBOV). In September 2014, a Liberian physician, Dr. Gorbee Logan, reported positive results while treating EVD with lamivudine (1). Thirteen of 15 patients treated with lamivudine survived presumed EVD and were declared virus free. Clinical confirmation of EVD in these cases remains to be verified....

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For Immediate Release February 11, 2015 FACT SHEET: Progress in Our Ebola Response at Home and Abroad

THE WHITE  HOUSE  PRESS OFFICE                                          FEB. 11, 2015

Fact sheet on the Ebola situation

"...Together with our international partners – and the people of the three nations themselves – we have bent the curve of the epidemic and placed it on a much improved trajectory. We have gone from over 1,000 new suspected, probable, and confirmed Ebola cases a week in October, to roughly 150 new confirmed weekly cases in the most recent reports.  Liberia has reported only a handful of new cases per week, a drop of well over 90 percent.  Significant declines also have been reported in Sierra Leone from the epidemic’s peak. Among the accomplishments in this response:..."

Read complete Statement
http://www.whitehouse.gov/the-press-office/2015/02/11/fact-sheet-progress-our-ebola-response-home-and-abroad

Also see:

Most U.S. Troops will be withdrawn, posted yesterday, Feb. 11, 2015

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UK should resume flights to Ebola-hit nations: parliamentary watchdog

REUTERS   by  Katie Nguyen                                                                                       Feb. 11, 2015

LONDON - Britain's decision to stop direct flights to Ebola-hit countries had "no scientific justification", probably increased the cost of dealing with the outbreak and should be reversed, a parliamentary watchdog said on Wednesday.

Several airlines including British Airways and Emirates stopped flights last year to countries in West Africa affected by the worst outbreak of Ebola since the deadly virus was identified in 1976.

In September, independent health advisers to the World Health Organization (WHO) concluded that there should be no general ban on travel or trade with Ebola-affected areas....

The committee also criticized the Department for International Development (DFID) for failing to respond to the crisis with enough urgency. It said DFID should focus on strengthening healthcare systems in the region so they could cope better with future public health emergencies.
Read complete story.

http://news.yahoo.com/uk-resume-flights-ebola-hit-nations-parliamentary-watchdog-132034795--finance.html;_ylt=AwrBEiHpi9tUnhAA7srQtDMD

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Reform After the Ebola Debacle

      

Margaret Chan, the director general of the World Health Organization.
Credit Salvatore Di Nolfi/Keystone, via Associated Press

nytimes.com - by The Editorial Board - February 10, 2015

The World Health Organization’s anemic performance in handling the Ebola outbreaks in West Africa may yield one positive outcome: sweeping, and long overdue, institutional reforms to improve its ability to respond more quickly to the next outbreak of a lethal infectious disease. Scrambling to answer growing criticism, the W.H.O.’s executive board recently endorsed changes to enhance the agency’s rapid response capabilities.

The reforms call for well-trained public health workers to rush to the aid of beleaguered countries and an emergency fund to support their initial operations, among other advances.

(READ COMPLETE ARTICLE)

(CLICK HERE - WHO - RESOLUTION AND SUPPORTING DOCUMENTATION)

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Ebola infection 'linked to visor'

THE PRESS ASSOCIATION                               Feb. 4, 2015
LONDON --A British nurse who contracted Ebola while working in Sierra Leone possibly caught the virus by wearing a visor and not goggles, an investigation has suggested.
Press Association - Save the Children said Pauline Cafferkey, pictured on her return to health, may have contracted Ebola by wearing a visor rather than goggles when treating patients in Sierra Leone

The report by Save the Children said it cannot be completely certain how Pauline Cafferkey contracted Ebola but said both pieces of equipment are "equally safe".

The nurse, from Cambuslang in South Lanarkshire, had volunteered with the charity at the Ebola Treatment Centre (ETC) in Kerry Town before returning to the UK in December....

Save the Children published the findings of an independent review into the possible causes of how the 39-year-old caught the virus. The report said both visors and goggles are safe but there are slight differences in the type of clothing worn with each and in the protocols for putting them on and removing them....

Read complete story.

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WHO names Ebola response chief

AFP                                                                      Feb. 3, 2015
GENEVA: The World Health Organization said Tuesday it had appointed its assistant director-general Bruce Aylward to head its overall response to the deadly Ebola outbreak.

It also said an independent commission was being created to assess WHO's widely criticised response to the epidemic, after the UN agency admitted last month it had been caught napping on Ebola and pledged reforms to avoid similar mistakes in the future.

WHO spokeswoman Fadela Chaib told reporters that Alward, a Canadian, will be responsible for coordinating all the different aspects of the agency's response to the devastating outbreak, which has killed nearly 9,000 people, almost all of them in Guinea, Sierra Leone and Liberia.

Read complete story.

 

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As Ebola Ebbs in Africa, Focus Turns From Death to Life

NEW YORK TIMES  by Normitsu Onishi                                                                Feb. 1, 2015

MONROVIA, Liberia — Life is edging back to normal after the deadliest Ebola outbreak in history....

FEAR FADING Beachgoers in Monrovia, Liberia, recently ravaged by Ebola. As fear of the virus ebbs, Liberians are slipping back into their daily rhythm. John Moore/Getty Images

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What worked in controlling the Ebola outbreak in West Africa

One Lesson: Rush to Help, not to declare victory

EDITORIAL    THE WASHINGTON POST                                Jan. 31, 2015

THE WORLD’S tardy response to the Ebola virus outbreak in West Africa, which has killed 8,810 people, demands that lessons be learned.

 Toward that end, a fresh batch of scientific reports has emerged in recent days to guide future responses. The World Health Organization, which stumbled in the initial period, seems to be recognizing its mistakes and looking for ways to correct them.... it is vital to keep medical interventions in place for long periods — and a big mistake to declare victory too early. The research also shows that most transmission of Ebola occurred in families....

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Estimating Food Consumption and Poverty Indices with Mobile Phone Data

submitted by George Hurlburt

arxiv.org - November 22, 2014
Adeline Decuyper, Alex Rutherford, Amit Wadhwa, Jean-Martin Bauer, Gautier Krings, Thoralf Gutierrez, Vincent D. Blondel, Miguel A. Luengo-Oroz
arXiv:1412.2595 [cs.CY]

Recent studies have shown the value of mobile phone data to tackle problems related to economic development and humanitarian action. In this research, we assess the suitability of indicators derived from mobile phone data as a proxy for food security indicators. We compare the measures extracted from call detail records and airtime credit purchases to the results of a nationwide household survey conducted at the same time. Results show high correlations (> .8) between mobile phone data derived indicators and several relevant food security variables such as expenditure on food or vegetable consumption. This correspondence suggests that, in the future, proxies derived from mobile phone data could be used to provide valuable up-to-date operational information on food security throughout low and middle income countries.

CLICK HERE - RESEARCH - Estimating Food Consumption and Poverty Indices with Mobile Phone Data

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Global Health Security: The Next Five Years

onlinedigeditions.com - Andrew C. Weber - Christine Parthemore

The next five years will see crucial changes in the global health security landscape, profoundly shaped by two key events in 2014:

The Ebola response in West Africa, and the successful first year of the Global Health Security Agenda, an initiative of dozens of countries and non-governmental organizations to make tangible commitments for preventing, rapidly detecting, and effectively responding to infectious disease threats.(1) 

Both events brought to light signs of measurable progress, and profound gaps that must be prioritized in the years ahead. Pressing needs include expanding emergency operations center capacity, better leveraging technological innovation, and closing the gap between the health and security communities.

(READ COMPLETE ARTICLE)

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