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How Ebola Adapted to Us

Ebola virus particles (blue) budding from an infected cell. National Institute of Allergy and Infectious Diseases, National Institutes of Health

Image: Ebola virus particles (blue) budding from an infected cell. National Institute of Allergy and Infectious Diseases, National Institutes of Health

theatlantic.com - November 3rd 2016 - Ed Yong

In December 2013, in a small village in Guinea, the Ebola virus left its traditional host—probably a bat—and infected a young boy. That leap triggered what became the largest Ebola outbreak in history. At first, the virus stayed within Guinea’s borders and, as in every previous epidemic, affected just a few hundred people.

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Beautiful New Images of Ebola Virus and Other Pathogens

When I told her that I wanted to major in microbiology, my best friend from childhood responded, “Are you sure you want to look in a microscope all day?”

But, as it turned out, a lot of microbiologists don’t use microscopes very often. I was one of them. The reason is because a substantial proportion of modern microbiology research uses the tools of molecular biology, for which microscopes are not needed.

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Each 1-Day Delay in Hospitalization Ups Risk of Ebola Death

US NEWS AND WORLD REPORT HEALTHDAY NEWS by Robert Preidt,  Nov. 6, 2015

Ebola patients are more likely to survive if they are hospitalized soon after being infected, a new study finds.

Researchers analyzed data from nearly 1,000 cases of Ebola virus that occurred in the Democratic Republic of Congo over 38 years. They found that each day of delay in hospital admission was associated with an 11 percent higher risk of death during epidemics.

Delays in hospitalization were caused by factors such as geography, infrastructure and cultural influences, the researchers said.

The Democratic Republic of Congo has had more Ebola outbreaks than any other country since the deadly virus was discovered in 1976, they noted.

The researchers also found that rapidly progressing Ebola outbreaks are swiftly brought under control, while national and international responses to slower-progressing outbreaks tend to be less intense. As a result, those outbreaks last longer, the study authors said.

The study was published Nov. 3 in the journal eLife.

Read complete story.

http://health.usnews.com/health-news/articles/2015/11/06/each-1-day-delay-in-hospitalization-ups-risk-of-ebola-death

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What ‘100 Percent Effective’ Means for That Ebola Vaccine

Analysis
WIRED.COM by Katie M. Palmer                                                            Aug. 4, 2015

Last week, the medical journal the Lancet published preliminary results on the efficacy of an Ebola vaccine in Guinea, and everybody got really excited—especially about one particular figure. The vaccine, the results suggested, was 100 percent effective at protecting against Ebola, a thrilling prospect in the face of an epidemic that has killed more than 11,000 people. ...

But that number probably means less than you think it does. It’s based on incomplete data, so it doesn’t have the statistical clout it should. And it never will. Based on the vaccine’s early success, the trial’s runners decided that all participants in the study should get it immediately after exposure. That’s a perfectly reasonable, humane reaction, but it also means that the researchers will never be able to collect better data on the vaccine’s efficacy, which is what regulators look for when they’re deciding to approve a drug. In other words, the vaccine’s early success could make it harder for people to get it down the line.

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Malaria morbidity and mortality in Ebola-affected countries caused by decreased health-care capacity, and the potential effect of mitigation strategies: a modelling analysis

LANCET by Patrick G. T. Walker and others                               Volume 15, No. 7, p825–832, July 2015
The ongoing Ebola epidemic in parts of west Africa largely overwhelmed health-care systems in 2014, making adequate care for malaria impossible and threatening the gains in malaria control achieved over the past decade. We quantified this additional indirect burden of Ebola virus disease.

We estimated the number of cases and deaths from malaria in Guinea, Liberia, and Sierra Leone from Demographic and Health Surveys data for malaria prevalence and coverage of malaria interventions before the Ebola outbreak. We then removed the effect of treatment and hospital care to estimate additional cases and deaths from malaria caused by reduced health-care capacity and potential disruption of delivery of insecticide-treated bednets. We modelled the potential effect of emergency mass drug administration in affected areas on malaria cases and health-care demand....

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Mining Ebola tweets yields valuable outbreak information

MEDICAL NEWS TODAY                                                    June 2, 2015
(Scroll down for study.)
Last year, in the 3 days before the outbreak was officially announced, over 60 million people received tweets about the Ebola outbreak in West Africa, say the authors of a new study published in the American Journal of Infection Control that investigates the useful role that Twitter can play in outbreak monitoring and control.


In the 3 days prior to Nigeria's official announcement about Ebola, Twitter users had already shared around 1,500 tweets about the outbreak....

Social media allow users to play active roles in spreading news. Users can share insights, opinions, fears and ideas, outside the contexts of conventional public health channels.

For their study, two researchers from Columbia University School of Nursing in New York, analyzed Ebola-related tweets posted over a week in the early stages of the West African outbreak - from July 24th to August 1st 2014....

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Evaluating Clinical Trial Designs for Investigational Treatments of Ebola Virus Disease

PLOS MEDICINE   by Ben Cooper and others                                                             April 14, 2015
Experimental treatments for Ebola virus disease might reduce EVD mortality. There is uncertainty about the ability of different clinical trial designs to identify effective treatments, and about the feasibility of implementing individually randomised controlled trials during an Ebola epidemic

A treatment evaluation programme for use in EVD was devised using a multi-stage approach (MSA) with two or three stages, including both non-randomised and randomised elements. The probabilities of rightly or wrongly recommending the experimental treatment, the required sample size, and the consequences for epidemic outcomes over 100 d under two epidemic scenarios were compared for the MSA, a sequential randomised controlled trial (SRCT) with up to 20 interim analyses, and, as a reference case, a conventional randomised controlled trial (RCT) without interim analyses.

Read complete study.

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001815

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Ebola virus not mutating as quickly as thought

SCIENCE NEWS  by Ashley Yaeger                                                      March 26, 2015

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The virus causing the current Ebola epidemic in West Africa is not evolving as quickly as some scientists had suggested.

REGULAR RATE  A genetic analysis suggests that the Ebola virus, shown here in orange, is not evolving as fast as expected.

In a paper last August, researchers reported that the virus (Zaire ebolavirus) was altering its genes almost twice as fast as it had during previous Ebola outbreaks in Central Africa (SN: 9/20/14, p. 7). However, a new genetic analysis shows that the virus is mutating at roughly the same rate as in past outbreaks, researchers report online March 26 in Science. The finding suggests the virus has not become more virulent or transmissible during the West Africa outbreak.

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Liberians overcome fear to volunteer for Ebola vaccine trial

ASSOCIATED PRESS  by Jpnathan Paye-Layleh             March 22, 2015

MONROVIA, Liberia — Liberians are overcoming their fears of Ebola to volunteer for a vaccine trial...

One year after the World Health Organization declared the Ebola outbreak, vaccine trials are under way in Liberia and Guinea. Sierra Leone will start a trial later this month.

In Liberia, scientists have fanned out across the country to explain the studies and reduce the fear and confusion that have stymied efforts to contain Ebola.

Dr. Stephen Kennedy, the Liberian lead investigator for the study, was among the first people to volunteer for the vaccine trial, getting his injection in front of the media. Similarly, in Guinea, authorities started the study by injecting a series of prominent officials, including the head of the country's Ebola response.

The outreach worked in Liberia, where more than 700 people have volunteered, well beyond the 600 required, according to Kennedy.

Read complete story.
http://news.yahoo.com/liberians-overcome-fear-volunteer-ebola-vaccine-trial-120848405.html

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