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Ebola Assay Card | Elisa-Based Diagnostic - Google Science Fair

submitted by Gavin Macgregor-Skinner

Temperature-Independent, Portable, and Rapid Field Detection of Ebola via a Silk-Derived Lateral-Flow System

googlesciencefair.com - 2015

I developed a “stable and stored at room temperature” Ebola Assay Card, applicable as an ELISA-based diagnostic for diseases such as HIV, Lyme and certain cancers, that will allow for water-activated, timed-release detection of Ebola antigens, with detection limits that are analogous to current sandwich ELISA techniques. Reagents become chemically “stabilized” when mixed into silk, which enables them to remain “chemically active” without refrigeration. This Ebola Assay Card will allow for shipment and storage without refrigeration, and provide detection of the Ebola viral antigens based on color change in as little as 30 minutes.

(CLICK HERE FOR ADDITIONAL INFORMATION)

 

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Fighting Ebola With a Palm-Sized DNA Sequencer

submitted by George Hurlburt

      

Raymond Koundouno using a MinION - Sophie Duraffour

The MinION, a pocket-sized, USB-powered sequencing machine, lets scientists track the spread of deadly diseases in real-time.

theatlantic.com - by Ed Yong - September 16, 2015

. . . Unlike rival sequencers, which are as big as microwaves or fridges, the MinION is the size of a chocolate bar. . . . These devices quite literally bring the power of modern genomics to the palm of your hand. And at a cost of just $1,000, they herald a new era where sequencing moves away from well-equipped institutions and into places where it is most needed, from hospitals to epidemic-afflicted hot zones.

(READ COMPLETE ARTICLE)

(CLICK HERE - MinION - Oxford Nanopore Technologies)

(CLICK HERE - YouTube - MinION - Oxford Nanopore Technologies)

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Offline: A pervasive failure to learn the lessons of Ebola

THE LANCET by Richard Horton                         Sept. 12, 2015

LONDON-- Post-Ebola reverie has given birth to a plethora of expert panels to consider what went wrong. The latest parade of global health specialists appointed to learn lessons gathered at the Wellcome Trust in London last week.
 Under the auspices of the US Institute of Medicine (IOM), a Commission to “deliberate and evaluate options to strengthen global, regional, and local systems to better prepare, detect, and respond to epidemic diseases” spent 2 days amassing evidence.

 There was no shortage of experience brought to bear on these important matters. Here were Margaret Chan, Jeremy Farrar, Ilona Kickbusch, David Heymann, Larry Gostin, Joy Phumaphi, Joanne Liu, and Peter Piot all wrestling with a seemingly intractable challenge. The statements offered to the Commission were arresting. But  the purpose of the meeting was not to talk. It was to identify the best system for an epidemic response....
Read complete article

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2815%2900152-X/fulltext

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WHO Vaccine-Preventable Diseases: Monitoring System - Country Summaries

                                       

apps.who.int

WHO Vaccine-Preventable Diseases: Monitoring System
(Click on the country of interest - then click "OK")
http://apps.who.int/immunization_monitoring/globalsummary

Country Summaries - WHO UNICEF Review of National Immunization Coverage, 1980-2014
(Click on the country of interest)
http://apps.who.int/immunization_monitoring/globalsummary/wucoveragecountrylist.html

 

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Survey Finds Many Physicians Overestimate Their Ability to Assess Patients’ Risk of Ebola

massgeneral.org - August 27, 2015

While most primary care physicians responding to a survey taken in late 2014 and early 2015 expressed confidence in their ability to identify potential cases of Ebola and communicate Ebola risks to their patients, only 50 to 70 percent of them gave answers that fit with CDC guidelines when asked how they would care for hypothetical patients who might have been exposed to Ebola. In addition, those who were least likely to encounter an Ebola patient – based on their location and characteristics of their patients – were most likely to choose overly intense management of patients actually at low risk.  The results of the survey, conducted by a team of Massachusetts General Hospital (MGH) investigators, have been published online in the Journal of General Internal Medicine.

(READ COMPLETE ARTICLE)

CLICK HERE - RESEARCH - Ebola Risk and Preparedness: A National Survey of Internists 

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WHO Director-General addresses the Review Committee of the International Health Regulations focused on the Ebola response

Opening remarks at the Review Committee on the role of the International Health Regulations in the Ebola outbreak and response Geneva, Switzerland by Dr. Margaret Chen Director-General of the World Health Organization
24 August 2015

....Since Ebola first emerged in 1976, WHO and its partners have responded to 22 previous outbreaks of this disease. Even the largest were contained within four to six months....

In West Africa, WHO, and many others, were late in recognizing the potential of the outbreak to grow so explosively. Some warning signals were missed. Why?

Our challenge now is to look for improvements that leave the world better prepared for the next inevitable outbreak.

Managing the global regime for controlling the international spread of disease is a central and historical responsibility of the World Health Organization. We need to pinpoint the reasons why the response fell short,. We need to learn the lessons. We need to put in place corrective strategies just as quickly as possible....

Read complete speech.

http://www.who.int/dg/speeches/2015/review-committee-ihr-ebola/en/

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With Many Ebola Survivors Ailing, Doctors Evaluate Situation

ASSOCIATED PRESS  by Carley Petesch              Aug. 23, 2015

DAKAR, Senegal --Lingering health problems afflicting many of the roughly 13,000 Ebola survivors have galvanized global and local health officials to find out how widespread the ailments are, and how to remedy them.

The World Health Organization calls it an emergency within an emergency. Many of the survivors have vision and hearing issues. Some others experience physical and emotional pains, fatigue and other problems. The medical community is negotiating uncharted waters as it tries to measure the scale of this problem that comes on the tail end of the biggest Ebola outbreak in history.

"If we can find out this kind of information, hopefully we can help other Ebola survivors in the future," Dr. Zan Yeong, an eye specialist involved in a study of health problems in survivors in Liberia, told The Associated Press.

About 7,500 people will enroll — 1,500 Ebola survivors and 6,000 of their close contacts — and will be monitored over a five-year period in the study launched by Partnership for Research on Ebola Vaccines in Liberia, or PREVAIL.

Read complete story.

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Ebola: What Happened

COUNCIL ON FOREIGN RELATIONS  BY John Campbell
(Scroll down for Laurie Garett's essay "Ebola's Lessons.")

With a rapidly growing and urbanizing population, persistent poverty, and weak governance, Sub-Saharan Africa is likely to be the source of new epidemics that potentially could spread around the world. Understanding the disastrous response of African governments, international institutions, and donor governments to the Ebola epidemic is essential if history is not to be repeated yet again. That makes Laurie Garrett’s essay, “Ebola’s Lessons,” in the September/October 2015 issue of Foreign Affairs, essential reading.

The Ebola virus treatment center where four people are currently being treated is seen in Paynesville, Liberia, July 16, 2015. (Courtesy Reuters/James Giahyue)

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Some Ebola Survivors Still Suffer—And Doctors Don’t Know Why

SCIENCE    by  Katie  M. Palmer                      Aug. 15, 2015

For the communities in Guinea, Sierra Leone, and Liberia where Ebola took the greatest toll last year, the worst is over. After claiming 11,000 lives, the fatal virus has finally begun to retreat. Numbers of new Ebola cases are dwindling. But for some of the survivors—the 50 percent or so of the infected who pull through—Ebola’s effects still linger.

                            Ebola survivor Fayiah, 11, sits with her relatives in Monrovia, Liberia. Jerome Delay/AP

For the communities in Guinea, Sierra Leone, and Liberia where Ebola took the greatest toll last year, the worst is over. After claiming 11,000 lives, the fatal virus has finally begun to retreat. Numbers of new Ebola cases are dwindling. But for some of the survivors—the 50 percent or so of the infected who pull through—Ebola’s effects still linger.

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Proposed Ebola biobank would strengthen African science

NATURE by Erika Check Hayden                                                                             Aug. 10, 2015
As West Africa’s Ebola outbreak winds down, an effort is under way to make the best use of the tens of thousands of patient samples collected by public-health agencies fighting the epidemic.  Samples from the Ebola epidemic in West Africa are held by public-health agencies in the region and abroad. Daniel Berehulak/NYT/Redux/Eyevine

On 6–7 August, the World Health Organization (WHO) convened a meeting in Freetown, Sierra Leone, to discuss how to establish a biobank for up to 100,000 samples of blood, semen, urine and breast milk from confirmed and suspected Ebola patients, as well as swabs taken from the bodies of people who died from the virus. Held by health agencies in both West Africa and the West, the samples could be valuable in understanding how the current Ebola crisis evolved, preparing for future outbreaks and developing public-health research capacity in a region that depends on outside experts.

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