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Probing Ebola's Deadly Inflammatory Effect

      

New research suggests that Ebola's deadly inflammatory effects may be caused by the result of protein shedding by infected cells. (Victor Volchkov / PLOS Pathogens)

CLICK HERE - RESEARCH - PLOS Pathogens - Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

latimes.com - by Monte Morin - November 20, 2014

New research suggests that the massive and destructive inflammation that characterizes Ebola virus disease may be caused by the release of foreign proteins from infected cells.

Although Ebola is infamous for causing bleeding in some of its victims, doctors say the vast majority of deaths are the result of organ failure and shock brought on by the uncontrolled release of cytokines, compounds that cells use to communicate with one another and control immune response. . .

. . . In a paper published Thursday in Plos Pathogens, researchers at the Claude Bernard University of Lyon, in France, argued that glycoprotein shedding by infected cells may explain the immune system's damaging response.

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UN security council criticises discrimination against those from Ebola-hit regions

THE GUARDIAN                                                    Nov. 21, 2014
THE UNITED NATIONS --The UN security council has criticized travel bans against nationals from Ebola-hit countries.

Last month the Australian immigration minster, Scott Morrison, announced Australia would stop granting temporary visas to visitors from west Africa. The security council statement criticised such blanket bans and urged countries to maintain links with affected countries.

“The security council expresses its continued concern about the detrimental effect of the isolation of the affected countries as a result of trade and travel restrictions imposed on and to the affected countries as well as acts of discrimination against the nationals of Guinea, Liberia, Mali and Sierra Leone,” said Julia Bishop, the Australian foreign mniister who was presiding over the session Thursday.

The council statement also described the Ebola outbreeak in Africa as "a threat to international peace and security..."

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Ebola Deaths Near 5,500 As Virus Still Rages

WALL STREET JOURNAL                                                                                               Nov. 21, 2014

By Andrew Morse

ZURICH—Nearly 5,500 people have died from Ebola, the World Health Organization said Friday, adding that the rate of transmission remains intense in the three West African countries at the center of the epidemic.

Medical staff members of the Croix Rouge NGO put on protective suits before collecting the corpse of a victim of Ebola, in Monrovia, Liberia. Agence France-Presse/Getty Images

In an update, the United Nations health agency said 15,351 confirmed, suspected or probable cases of Ebola had been reported in eight countries that have been affected by the disease. Most of the cases were concentrated in Guinea, Liberia and Sierra Leone.

A total of 5,459 people have died of Ebola since the outbreak began, the WHO said. On Wednesday, the WHO reported 15,145 cases and 5,420 deaths.

Ebola’s true overall toll is difficult to gauge because some hard-hit villages are remote and urban centers have showed resistance toward clinics....

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WHO Declares End to Ebola Outbreak in DRC

VOICE OF AMERICA                                                                                                       Nov. 21, 2014

The World Health Organization has declared an end to the Ebola outbreak in the Democratic Republic of Congo.

The outbreak -- unrelated to the one affecting West Africa -- was centered in Congo's northwestern Equateur province and killed at least 49 people.  Nurses from Uganda’s Ministry of Health check passengers arriving from Democratic Republic of Congo, Central Africa at Entebbe Airport Kampala Uganda, Friday, Aug. 8, 2014.

The WHO released a statement Friday saying it has been 42 days, or twice the maximum incubation period, since a new case of Ebola has been detected in the DRC.

The WHO declaration confirms a statement by the DRC government last week that the outbreak there is over.

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http://www.voanews.com/content/who-declares-end-to-ebola-outbreak-in-drc/2529068.html

See complete WHO statement

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Researchers Develop Real-Time Monitoring for Ebola Outbreaks

VOICE OF AMERICA                                                                                                        Nov. 20, 2014
By Joe DeCapua
Knowing where the Ebola hot spots are in a country is crucial to getting an outbreak quickly under control. Many have criticized the initial slow response to the West Africa outbreak, saying it’s a big reason the virus quickly spread. Now, a German research center is developing a project to monitor Ebola and other outbreaks in real time.

Professor Gérard Krause said the new project – called EBOKON – uses real-time monitoring to better manage an outbreak.Krause is head of the Department of Epidemiology at the Helmholtz Center for Infection Research – and EBOKON project leader for the German Center for Infection Research....

He said, “This is an information technology tool that we are developing together with colleagues from Nigeria that will take care of all those management aspects.”

The EBOKON project calls for setting up a command center, so to speak, in the capital of affected countries. Then health workers would use cellphones to relay in real time information on suspected cases around the country.

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U.S. to allow people from nations hit by Ebola to stay temporarily

REUTERS                                                                                                                      Nov. 20, 2014
By Julia Edwards

WASHINGTON-- The Department of Homeland Security will grant temporary protected status to people from the three West African countries most affected by Ebola who are currently residing in the United States, department officials said on Thursday.

A U.S. Coast Guard Corpsman working with the Office of Field Operations checks the temperature of a traveler who has recently traveled to either Guinea, Sierra Leone, or Liberia in this handout picture from the U.S. Customs and Border Protection taken at Washington Dulles International Airport October 16, 2014.Credit: Reuters/U.S. Customs and Border Protection/Josh Denmark/Handout via Reuters

People from Liberia, Guinea, and Sierra Leone in the United States as of Thursday may apply for protection from deportation, as well as for work permits, for 18 months, said a Department of Homeland Security official.

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Ebola response in Liberia is hampered by infighting

NEW YORK TIMES                                                                                                      Nov. 20, 2014
By Donald G. McNeil Jr.

The global response to the Ebola virus in Liberia is being hampered by poor coordination and serious disagreements between Liberian officials and the donors and health agencies fighting the epidemic, according to minutes of top-level meetings and interviews with participants. Medical workers handling a blood sample of an Ebola victim as the girl, 9, lay in a shawl in Monrovia, Liberia. She later died. Credit Daniel Berehulak for The New York Times

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Queen Fears Ebola Push at Expense of Other Killer Diseases

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Ebola's impact on Africa economy might be less than feared

REUTERS                                                                                                                             nOV. 19, 2014         
By Joe Brock
JOHANNESBURG (Reuters) - The cost of the Ebola epidemic for Sub-Saharan Africa's economy is likely to be closer to $3 billion-$4 billion and not the worst-case scenario of $32 billion, the World Bank's chief economist for the continent said on Wednesday.

Francisco Ferreira said at a lecture in Johannesburg that successful containment of Ebola in some West African countries made the gloomiest forecasts less likely, but the economic damage could still escalate if there was any complacency.

"The risk of the highest case of economic impact of Ebola has been reduced because of the success of containment in some countries. It has not gone to zero because a great level of preparedness and focus is still needed," Ferreira said.

"I would say the outlook has moved closer to the lower case of $3-$4 billion, than the upper case," he said.

In a report in October, the World Bank said that if the Ebola epidemic spread significantly outside the epicentre states of Guinea, Sierra Leone and Liberia, the potential cost for Africa in disrupted cross-border trade, supply chains and tourism could amount to tens of billions of dollars.

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West African Mining Projects Take Hit From Ebola Crisis

Epidemic Delays Rollout of Jobs Meant for Residents of Guinea, Liberia and Sierra Leone

WALL STREET JOURNAL                                                                                             Nov. 19, 2014
By Patrick McGroarty in Liberia, David Gauthier-Villars in Guinea
and Alex MacDonald in London

...a promising corner of the global economic frontier is pocked with stalled mining projects. The Ebola epidemic has scared off ships and planes; prompted expatriates to abandon their posts; and delayed the rollout of thousands of jobs meant for residents of the three poor West African countries hardest hit by the virus: Guinea, Liberia and Sierra Leone.

A three-story steel shiploader at ArcelorMittal’s port in the Liberian city of Buchanan is part of a $1.7 billion expansion delayed by Ebola. Patrick McGroarty/The Wall Street Journal

“All the projects are at a standstill,” said Mr. Foulah, chief executive of the mining-explosives firm ECP Guinée.

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EU boosts anti-Ebola aid after Commissioners' mission to worst-hit countries

EUROPEAN COMMISSION HUMANITARIAN AID DEPARTMENT   Nov. 17, 2014

The European Union is continuing to scale up its response to the Ebola epidemic as its Coordinator for the emergency, Commissioner Christos Stylianides together with Vytenis Andriukaitis, Commissioner for Health, return from a four-day mission to the affected countries.

New funding of €29 million will be made available by the European Commissionfor transporting vital aid supplies and equipment to the affected countries, evacuation of infected international aid workers to hospitals in Europe and training and deploying health workers to the ground. Money will also reinforce local health facilities.

Of this total, €12 million is for assistance to the neighbours of the affected countries, to help them prepare for the risk of an Ebola outbreak through early detection and public awareness measures.

... The European Union's total contribution is close to €1.1 billion.

Sweden has announced that it will deploy, via the EU Civil Protection Mechanism, 42 doctors, nurses and other health personnel who will run a treatment centre on the ground.

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Benin: Authorities Rule Out the Ebola Track After a Series of Deaths

      

Rue de Cotonou au Bénin - Getty Images/Raido Valjamaa

(ENGLISH TRANSLATION PROVIDED BELOW)

Bénin: les autorités écartent la piste Ebola après une série de décès

rfi.fr/afrique - November 18, 2014

Interrogation et inquiétude au Bénin après le décès de plusieurs personnes à l’hôpital de Tanguiéta situé dans le nord-ouest du pays. Ces décès, survenus en moins d’un mois, concernent le personnel de santé. Les tests Ebola sont négatifs et la ministre de la Santé a tenu, lundi, une conférence de presse pour rassurer la population.

C’est la semaine dernière que le ministère de la Santé a été informé du décès de trois agents de l’hôpital St Jean de Dieu de Tanguiéta. Parmi eux, il y aurait deux infirmières en néonatologie. Vendredi, c’est un pédiatre qui est mort à Porto-Novo où il avait été transféré.

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Africa’s Village Healers Complicate Ebola Fight

In Sierra Leone, Traditional Treatments and Death of a Woman Who Resisted Outside Help Fostered Outbreak

WALL STREET JOURNAL                                                                                                      Nov. 18, 2014
By Peter Wonacott
KAILAHUN, Sierra Leone—When a Red Cross volunteer visited this impoverished border district in mid-May to warn about the spread of Ebola, he faced a formidable adversary: the village healer.

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Beating Ebola Means Drinking, Last Thing Patient Wants to Do

BLOOMBERG BUSINESSWEEK                                Nov. 17, 2014
by Jason Gale

The best medical advice for surviving Ebola right now might fit in one word: drink.

Dr. Fadipe Akinniyi Emmanuel, Ebola survivor, shows the daily dose of oral rehydration salts, or ORS, he and other survivors took to survive in Nigeria. Photographer: Andrew Esiebo/World Health Organization via Bloomberg

With targeted drugs and vaccines at least months away, doctors and public health experts are learning from Ebola survivors what simple steps helped them beat the infection. Turns out drinking 4 liters (1 gallon) or more of rehydration solution a day -- a challenge for anyone and especially those wracked by relentless bouts of vomiting -- is crucial. “When people are infected, they get dry as a crisp really quickly,” said Simon Mardel, an emergency room doctor advising the World Health Organization on Ebola in Sierra Leone. “Then the tragedy is that they don’t want to drink.”

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Fear of Ebola Opens Wary Villages to Outsiders in Guinea

In-depth description of the Ebola situation in remote villages in Guinea

A man with symptoms of Ebola walked to the center of Dandano after the chief of the village ordered the removal of sick people from homes. “Bring out your sick!” the chief shouted at the crowd, shaking his fist and warning of illness and death for the whole village if they did not obey. Samuel Aranda for The New York Times

NEW YORK TIMES                                                                                                             Nov. 17, 2014
By Adam Nossiter

DANDANO, Guinea--

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