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Lack of Effect of Lamivudine on Ebola Virus Replication

CDC EID JOURNAL by  Lisa E. Hensley, Julie Dyall, Gene G. Olinger, and Peter B. Jahrlin (NIH)                     Feb. 12, 2015

The unprecedented number of Ebola virus disease (EVD) cases in western Africa has compelled the world to consider experimental and off-label therapeutics to mitigate the current outbreak. For clinicians, approved drugs are an attractive solution because of known safety profiles and availability.

Oral lamivudine (GlaxoSmithKline, Brentford, UK), a US Food and Drug Administration–approved anti-HIV drug, has been suggested as a possible antiviral agent against Ebola virus (EBOV). In September 2014, a Liberian physician, Dr. Gorbee Logan, reported positive results while treating EVD with lamivudine (1). Thirteen of 15 patients treated with lamivudine survived presumed EVD and were declared virus free. Clinical confirmation of EVD in these cases remains to be verified....

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For Immediate Release February 11, 2015 FACT SHEET: Progress in Our Ebola Response at Home and Abroad

THE WHITE  HOUSE  PRESS OFFICE                                          FEB. 11, 2015

Fact sheet on the Ebola situation

"...Together with our international partners – and the people of the three nations themselves – we have bent the curve of the epidemic and placed it on a much improved trajectory. We have gone from over 1,000 new suspected, probable, and confirmed Ebola cases a week in October, to roughly 150 new confirmed weekly cases in the most recent reports.  Liberia has reported only a handful of new cases per week, a drop of well over 90 percent.  Significant declines also have been reported in Sierra Leone from the epidemic’s peak. Among the accomplishments in this response:..."

Read complete Statement
http://www.whitehouse.gov/the-press-office/2015/02/11/fact-sheet-progress-our-ebola-response-home-and-abroad

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Most U.S. Troops will be withdrawn, posted yesterday, Feb. 11, 2015

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Global Health Security: The Next Five Years

onlinedigeditions.com - Andrew C. Weber - Christine Parthemore

The next five years will see crucial changes in the global health security landscape, profoundly shaped by two key events in 2014:

The Ebola response in West Africa, and the successful first year of the Global Health Security Agenda, an initiative of dozens of countries and non-governmental organizations to make tangible commitments for preventing, rapidly detecting, and effectively responding to infectious disease threats.(1) 

Both events brought to light signs of measurable progress, and profound gaps that must be prioritized in the years ahead. Pressing needs include expanding emergency operations center capacity, better leveraging technological innovation, and closing the gap between the health and security communities.

(READ COMPLETE ARTICLE)

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Lessons from Ebola: Toward a Post-2015 Strategy for Pandemic Response


Broadcast live streaming video on Ustream

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worldbank.org - Date: January 27th 2015 - Location: Georgetown University & Online Time: 4:00 p.m. - 5:00 p.m. ET (21:00 - 22:00 GMT)

Jim Yong Kim, President of the World Bank Group, will deliver Georgetown’s inaugural Global Futures lecture.

The lecture, “Lessons from Ebola: A post-2015 strategy for pandemic response,” will kick off a semester-long conversation about the “Global Future of Development” at Georgetown as part of the university’s new Global Futures Initiative.

His talk on Jan. 27 will connect ongoing efforts to stop the spread of infection in West Africa with longer-term efforts to improve public health systems that support economic and social development in countries vulnerable to future pandemics.

http://live.worldbank.org/lessons-from-ebola-post-2015

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Studies detail Ebola spread, response steps

Four new studies shed new light on Ebola transmission and countermeasures.

CENTER FOR EFFECTIVE FOR RESEARCH AND POLICY  by Lisa Schnirring                                        Jan. 23, 2015

French and Guinean researchers  noted how chains of transmission helped Ebola spread in Conakry, Guinea, the first of the region's capital cities to be hit by the virus, and US officials released three detailed reports on outbreak response.

The Conakry team looked at seven transmission chains that occurred in the area from March to August 2014. They reported their findings in The Lancet Infectious Diseases.

In the first of three reports Friday in Morbidity and Mortality Weekly Report (MMWR), extra flight contact tracing measures undertaken after a Texas nurse took two flights shortly before getting sick with Ebola in October identified 268 people from nine states, none of whom got sick with the virus

In the second report, CDC estimates on the impact of Ebola treatment units (ETUs) and community care centers (CCCs) in Liberia predict that the interventions prevented thousands of new infections and that the interventions when used together were likely had a bigger impact than either alone.

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Report by the Director-General to the Special Session of the Executive Board on Ebola

 

Statement by Dr. Margaret, Director-General of the World Health Organization to a Special Session of the Executive Board on Ebola

WHO PRESS OFFICE, Geneva                                                                                       Jan. 25, 2015

Excerpt:

"The Ebola outbreak points to the need for urgent change in three main areas: to rebuild and strengthen national and international emergency preparedness and response, to address the way new medical products are brought to market, and to strengthen the way WHO operates during emergencies."

Read complete statement.

http://www.who.int/dg/speeches/2015/executive-board-ebola/en/

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WHO Board Agrees on Reforms to Fix Ebola Response Mistakes

GENEVA-- The World Health Organization’s board agreed to create a special fund to respond to such outbreaks as Ebola and to set up a global health emergency workforce after the organization acknowledged mis-steps in its response to the epidemic.

 The WHO’s executive board agreed “in principle” at a meeting in Geneva Sunday to a contingency fund, and asked Director General Margaret Chan to develop by May options on its size and sources. Chan should also take immediate steps to establish a public-health reserve workforce that can be promptly deployed in response to health emergencies, according to the resolution adopted by senior health officials from 34 countries.

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Flu & Drug Resistance Are Next Pandemic Threats After Ebola

REUTERS    By Ben Hirschler                                   Jan. 23, 2015

DAVOS, Switzerland, Jan 23 (Reuters) - The worst-ever Ebola epidemic is waning, but after ravaging three West African nations and spreading fear from Dallas to Madrid, it has hammered home the message that the world needs a better detective system for emerging diseases.

Risks posed by pandemic threats such as deadly strains of flu and drug-resistant superbugs have shot up the agenda of global security issues at this year's World Economic Forum in Davos as politicians and scientists grapple with the lessons from an Ebola outbreak that has killed more than 8,600 people.

One thing is certain: more epidemics are coming and dense urban living, coupled with modern travel, will accelerate future infectious disease outbreaks.
Read complete story.
http://www.huffingtonpost.com/2015/01/23/flu-drug-resistance_n_6531066.html

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Ebola ebbing in West Africa but vigilance needed: WHO

REUTERS by Stephanie Nebehay                                                                        Jan. 22, 2015

GENEVA (Reuters) - The Ebola epidemic in West Africa appears to be ebbing, with fewer than 150 cases reported in the past week, but efforts must be pursued to stamp out the deadly disease, the World Health Organization (WHO) said on Thursday.

Sierra Leone remains hardest-hit, accounting for 117 of the 145 new confirmed cases, against 184 there the previous week and 248 the week before that, the WHO said in its latest update.

"Case incidence continues to fall in Guinea, Liberia, and Sierra Leone," the United Nations agency said, adding that disease surveillance was being stepped up in border districts of Guinea-Bissau, Ivory Coast, Mali and Senegal....

The WHO's Emergency Committee on Ebola said on Wednesday that passengers should still be screened on leaving Guinea, Liberia and Sierra Leone for temperature or other signs of infection.

The independent experts said in a statement that "more than 40 countries have implemented additional measures, such as quarantine of returning travellers and refusal of entry. Such measures are impeding the recruitment and return of international responders.

Read complete story.

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Ebola Response Provides Key Lessons for Risk Communications

Commentary: The CDC fumbled initial communications about Ebola transmission but recovered. What about next time?

EMERGENCY MANAGEMENT  by Jim McKay                                                              Jan. 13, 2015

It would be interesting to see what would happen if there was another Ebola scare in the U.S. The answer might depend on when it happened and perhaps where the person became infected. But chances are the health infrastructure would handle it, and perhaps respond to another infectious disease outbreak much better, having had the experience that the recent Ebola episodes provided.

That experience included hiccups and communication errors that resulted not in panic but disagreement on the part of some in the health community and alarm in the public. One target of criticism is the Centers for Disease Control and Prevention (CDC), which was confident from the beginning in expressing that hospitals throughout the U.S. were ready to handle Ebola cases and messaging to the public about the difficulty of transmission of the infection. The CDC chose not to participate in this discussion....

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